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Treatment protocols such as Inflammation Therapy resolve chronic inflammatory symptoms by stimulating the immune system to eliminate persistent pathogens. The resulting cellular death provokes Jarisch-Herxheimer reactions (i.e., immunopathology) which often cause hormonal, endocrine, and blood count changes.

The kidneys may be affected by subclinical chronic inflammation, and must function well enough to eliminate additional toxins released as a result of the bacterial die-off. Mildly abnormal kidney function during treatment is common and not a cause for concern. However, because treatment often requires many years of immune system stimulation to resolve inflammation, it's vital that medical practitioners regularly monitor kidney function (BUN, creatinine, eGFR, proteinuria, electrolytes, B/P, 24 hour urine, cystatin C, etc.) to ensure these markers of health don't stray too far from normal and aren't continuing to trend in the wrong direction.

Kidney function lab results that are seriously out of range should not be ignored nor should they be considered a normal part of the healing process. Seriously out of range kidney function tests do indicate renal stress that could result in permanent organ damage if waste products are allowed to accumulate. Anecdotal case reports include patients who have had to discontinue the treatment protocol in order to avoid dialysis.

However, the medical professionals at CIR have learned that reducing immunostimulation (i.e., upregulation of vitamin D receptor transcription of antimicrobial peptides) by decreasing the dose of Benicar (olmesartan) is an effective strategy to improve worrisome kidney function so patients can safely continue Inflammation Therapy. See Benicar Dose.