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Both Benicar® and Minocycline, two mainstays of Inflammation Therapy (IT), are contraindicated during pregnancy and while breastfeeding.

Benicar® warning
 
When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, Benicar® should be discontinued as soon as possible.
 
Minocycline warning
 
Minocycline, like other tetracycline-class antibiotics, can cause fetal harm when administered to a pregnant woman.
 
Inflammation Therapy
 
Inflammation Therapy may be started after delivery and when the baby is weaned.
 
Birth control
 
As Inflammation Therapy resolves inflammation, this healing may restore sexual capability and fertility. Therefore, women of childbearing age who are on IT are advised to use adequate birth control measures to avoid an unwanted pregnancy. Patients should consult their doctor regarding the form of birth control that is most appropriate for them.
 
Adjustment to birth control
 
It is recommended that women take their newly prescribed birth control pills for one menstrual cycle to assess the effect of the hormonal changes before starting Inflammation Therapy.
 
Patients are cautioned that Minocycline can interfere with some birth controls' contraceptive ability. The doses of Minocycline on IT are much smaller than usually used, although longer, but the warning might still apply. Patients may not want to take a chance on relying on the pill alone for birth control. If there is any uncertainty, patients should err on the side of caution.
 
Pregnancy increases 1,25-D
 
During pregnancy the hormone 1,25-D is over-expressed in the endometrium which may allow intracellular bacteria to proliferate.
 
This may be why women with Th1/Th17 inflammation may feel better during their pregnancy (elevated 1,25-D can inhibit immune system function) and there is a high rate of diagnosis of Th1/Th17 inflammatory disease post-partum.