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Inflammation Therapy (IT) is a recently developed method of treating chronic inflammation which is within the realm of western medicine; it does not fall under the category of alternative or complementary medicine (e.g., acupuncture, homeopathy, Aruyveda, etc).

The practice of Inflammation Therapy evolved from theories based on current scientific evidence and only uses prescription medications (an angiotensin receptor blocker and oral antibiotics). These medications are used off-label; that means they're prescribed for uses other than what the FDA has approved. This is legal and common; about one in five prescriptions are written off-label (May 23, 2012 Consumer Reports).

The doses and schedules of these medications are specific to Inflammation Therapy but are within the boundaries of standard medical practice and FDA-approved doses. Clinical practice has demonstrated the safety and success of this unique approach to treating autoimmune and inflammatory conditions which are resistant to other treatments. Many doctors are taking advantage of this emerging new drug use because their patients cannot afford to wait for formal proof of efficacy.

Following is a brief summary of the components of Inflammation Therapy.


A low dose of Benicar® (olmesartan medoxomil), an Angiotensin Receptor Blocker (ARB) is taken at regular intervals. Benicar® appears to agonize the vitamin D receptor (a key component of the immune system), thus apparently improving immune system function so the bacteria are eliminated.

"Modulation of the renin-angiotensin-aldosterone system (RAAS) with inexpensive, safe pharmaceuticals used by millions worldwide is an attractive therapeutic strategy for application to human autoimmune diseases."
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.


Chronic, degenerative inflammatory diseases are thought to be due to immune system dysfunction caused by persistent, intracellular bacteria. See Intracellular Bacteria Cause Inflammatory Diseases.

A select group of bacteriostatic antibiotics is taken orally at low doses, specific intervals and various combinations. They appear to weaken intracellular bacteria by blocking protein synthesis associated with bacterial reproduction. Thus. making it easier for the immune system to kill the bacteria.
See Immunomodulatory Properties of Antibiotics.

Vitamin D

25-D is maintained at a level that won't inhibit immune system function. Some will need to avoid foods and supplements containing natural and manufactured vitamin D to achieve this goal. 

Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1.

Ultraviolet light

Most patients find they need to avoid exposure to natural light falling on the skin to prevent inflammatory symptoms caused by production of vitamin D, and to avoid bright artificial light falling on the eyes which can also increase symptoms via stimulation of the amygdala.This study found that "Exposure to ultraviolet light, especially UVB wavelengths, can impair immune responses in animals and humans."

Herxheimer reations

The hallmark of an effective IT response is an intermittent increase in symptoms due to bacterial die-off, which occurs in a waxing and waning pattern before eventual, gradual resolution of symptoms. This phenomenon is known as the Jarisch-Herxheimer Reaction and is often referred to informally as herx or herxing.

Patient management of treatment

IT is a proactive therapy. Patients, or their caregivers, are expected to learn assessment and management techniques, including assessing medication response, to help their physician keep symptoms tolerable during the recovery process.


Based on anecdotal reports, Inflammation Therapy is showing a high response and recovery rate.
Recovery Reports
Efficacy and Expectations of Inflammation Therapy

See also:
Inflammation Therapy
(a simple introduction suitable for printing and sharing with friends and family.)